Code: 5010
Neutrophilic Segmentation Profile
A specialized profile assessing vitamin B12 and folate deficiency by evaluating the morphology of neutrophil white blood cells.
In the absence of infection or major chronic illness, excessive neutrophil segmentation can indicate folate or B12 deficiency.
- Microscopic analysis
- Vitamin B12 & folate indicator
- Same-day sensitivity
- Clinician-ready report
What This Test Measures
Neutrophil Morphology
Segmentation patterns (3–5 lobes normal)
- Hypersegmented neutrophils (>5 lobes)
- Early signs of macrocytic anemia
- Indirect B-vitamin status markers
- Folate-specific deficiency patterns
Clinical Relevance
Nutrient and metabolic health
- Low B12/folate → impaired methylation
- Increased homocysteine (CV risk)
- Insulin resistance / Type 2 diabetes
- Hormonal & detoxification imbalances
View CPT Code
Why It Matters
Neutrophils live roughly five days—making them highly responsive indicators of
nutritional changes. When folate or B12 levels are low, new neutrophils fail to
form properly, leaving older cells in circulation that show hypersegmentation,
a hallmark sign of deficiency.
When to Consider This Test
- Unexplained anemia or fatigue
- Persistent nutrient deficiency despite supplementation
- Suspected malabsorption
- Elevated MCV or homocysteine
- Hormonal or detox-related imbalances
How It Compares
Unlike red blood cell indices (MCV/MCH) which change over 120 days,
the Neutrophilic Segmentation Profile can reflect improvements
within days of B12 or folate supplementation, making it a valuable
monitoring tool for treatment response.
